Austell Piascledine Osteoarthritis 300 30's
Piascledine 30 Capsules is a daily supplement made with selected ingredients to help tackle the symptoms of osteoarthritis, including aches and pains, and mobility difficulties.
Piascledine® (300 mg capsules). Composition: Each capsule contains: Unsaponifiable extract (ASU 300) corresponding to: Persea gratissima oil unsaponifiable - 100 mg. Glycine max. (L) oil unsaponifiable - 200 mg. Excipients: Colloidal anhydrous silica. Butylhydroxytoluene. Pharmacological classification: A 34 other/complementary/western herbal medicines. Pharmacological action: Piascledine® belongs to the class of "SYSADOA" (symptomatic slow-acting drugs in osteoarthritis). The mechanism of action of the active substances in Piascledine® has been assessed through in-vitro and in-vivo studies in osteoarthritis, and showed the following: 1) Direct and indirect effects to promote the synthesis of cartilage extracellular matrix macromolecules (anabolic pathway): Increase in the proteoglycans synthesis by normal as well as osteoarthritis articular chondrocytes, especially those of high molecular weight, with a quality similar to physiological proteoglycans. Inhibition of proteoglycans degradation. Stimulation of the synthesis and accumulation of aggrecans (major proteoglycans in cartilage) in osteoarthritis chondrocytes. Stimulation of the type II collagen production by synoviocytes and articular chondrocytes. Prevention of the inhibitory effect of osteoarthritic subchondral osteoblasts on aggrecan and type II collagen synthesis by chondrocytes, in a co-culture model. Stimulation of the expression of factors such as TGF- β1 and TGF-β2. 2) Effects to limit the degradation of cartilage extracellular matrix components (catabolic pathway): Inhibition of the negative effects of IL-1β on collagen and aggrecan production. Inhibition of the stimulatory effect of IL-1β at increasing the collagenolytic activity in synovial cells and chondrocytes. Inhibition of the IL-1β-induced synthesis and activity of the collagenase (MMP-13) and stromelysin (MMP3) in chondrocytes. Reduction of IL-6 and IL-8 proinflammatory cytokine production as well as IL-1β-induced overproduction of PGE2. Stimulation of the plasminogen activator inhibitor 1 (PAI-1). All these effects account for a potential beneficial effect of Piascledine® on the repair and protection of the cartilage extracellular matrix components. 3) Structure-modifying effect and reduction of joint cartilage deterioration: In a randomized, double-blind, placebo-controlled, 3-year study (ERADIAS, 2010) was designed to assess the potential structure-modifying effects of Piascledine® once daily in patients with hip osteoarthritis, using repeated X-ray measures of the hip joint space width (JSW) as the main efficacy criterion. In accordance with oarsiomeract recommendations, the assessment of efficacy was also made by calculating the proportion of patients with osteoarthritis progression, i.e. patients with a JSW loss ≥ 0.5 mm over 3 years.
This study showed a significant reduction (p = 0.04) of joint cartilage deterioration, through a relative risk reduction of 20%, for patients to experience osteoarthritis progression when treated with Piascledine®, compared with placebo. 4) Sparing effects of Piascledine® on nonsteroidal anti-inflammatory drugs (NSAIDs): In clinical studies where the potential NSAIDs-sparing effect of Piascledine® was assessed, it was shown that, in patients with hip or knee osteoarthritis, the mean dosage of NSAIDs (standardized as diclofenac mg-equivalent) was reduced by about 60 tablets of diclofenac 25 mg monthly. The reduction or discontinuation of NSAIDs was decided upon patient's will, according to his/her symptom improvement during the treatment. Indications: Piascledine® is used in adults for the relief of symptoms of osteoarthritis, such as pain and difficulties when moving. Also refer to pharmacological action; points 3 and 4. Identification: Piascledine® is available as capsules with an orange cap and opaque grey body marked 'P300'. Presentation: Heat-formed PVC blister and aluminium foil containing 15 capsules. Cardboard box containing: 1 blister of 15 capsules or 2 blisters of 15 capsules each (30 capsules). Not all pack sizes may be marketed
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No more returns on international orders
Please note that due to new Covid-19 related rules, the South African Government no longer allows returns of medicines from abroad. If your parcel is refused entry into your country and marked "Return-to-Shipper", we will not be able to receive your returned parcel. Instead it will be destroyed by the S.A Customs Department upon arrival.
How to return an item from within South Africa
If you need to return an item, please follow these simple steps
28 day cooling off period
If you would like to return an item please notify us within 14 days of your order being delivered. You then have a further 14 days to return the item back to us. This gives you a maximum of 28 days in total to return an item.
You can contact us by completing the form on our contact us page, selecting 'returns' from the drop-down menu. Alternatively, you can notify a member of our Customer Care team on 011 568 3064.
Please note that we are unable to accept returns for the following unless they are damaged or faulty:
- Perishable items.
- Unsealed items with a protective seal due to health protection or hygiene reasons.
- Medicinal products or services that are dispensed on prescription.
Please note, this does not affect your statutory rights.
Where do I send returns?
Once our Customer Care team have been notified, please arrange postage to:
F.A.O: Returns Department25 Adderley St
Cape Town City Centre
Cape Town
8000
South Africa.
Unfortunately, we're unable to cover the costs of returning your items and cannot be liable for any damages incurred during transit. Please ensure they are properly secured and packaged and we'd recommend sending all returns via a recorded delivery service.
How long will it take to process my refund?
We aim to process your refund within 3-5 working days of receiving your item, however it can take up to 30 days to receive the refund via the original payment method.
Once you've cancelled the contract, you have a legal 'duty of care' to keep the items in a good condition and return them at your expense. We are entitled to deduct an amount from the refund to reflect any loss of revenue in the value of goods supplied which may be 100%, if the loss is the result of unnecessary handling of the goods by you.
In accordance with the Consumer Protection Act, Regulations 68 of 2008, we will refund you the full amount paid for the items returned within 14 days of receipt of the notice of cancellation.
To read out full terms and conditions, please click here.
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