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Your items may arrive sooner than the estimated delivery date. Ralph Lauren reserves the right to send packages via other shipping methods based on the shipping destination as long as orders will still arrive within the arrival times outlined on RalphLauren.com.
When you choose the Economy delivery option, packages are delivered Monday through Saturday 8 AM to 4:30 PM. Orders sent by Fast, 2-Business-Day or Next-Day shipping methods are delivered Monday through Friday from 8 AM to 4:30 PM.
We recommend choosing Fast or Next-Day delivery if you are shipping your package to a business address. You will be asked to provide a telephone number on the shipping page of checkout, which is important in the event the courier needs to arrange a delivery time with you.
You will also be asked to provide an email address, to which we will send confirmation that your order was placed.
Aciclovir has antiviral activity that is essentially confined to the herpes viruses. It is particularly active in vitro against herpes simplex type 1 and herpes simplex type 2. Aciclovir inhibits viral replication by inhibiting DNA synthesis. This inhibition is due to intracellular conversion of aciclovir by viral thymidine kinase to the monophosphate with subsequent conversion to the diphosphate and the active triphosphate. This active form inhibits the herpes virus DNA polymerase enzyme as well as being incorporated into viral DNA .
Aciclovir is effective in the treatment of viral infections due to herpes simplex type 1 and type 2 of the skin and genitalia in the initial and recurrent situation.
Application to the lips in the early treatment of recurrent Herpes simplex virus infections.
Topical applications of aciclovir may sometimes produce burning or erythema.
The topical cream may be applied five or six times daily every three or four hours for periods of five to ten days. Topical treatment of lesions caused by herpes simplex should be initiated as early as possible. It is particularly important to start treatment of recurrent episodes during the prodromal period or when the lesions first appear.
Aciclovir may sometimes cause transient burning or stinging. Erythema or mild drying and flaking of the skin have been reported.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT
See side-effects and special precautions. Should aciclovir need to be removed, then haemodialysis would be effective. Further treatment is symptomatic and supportive.